Pharmaceutial Intermediates
  • 2-Butyn-1-ol

    • Product Name   :   

      2-Butyn-1-ol

    • CAS No   :   

      764-01-2

    • Project State   :   

      Commercial

    Application

    General Description

    Cost-effective and customizable 2-Butyn-1-ol 764-01-2 in stock

    • Molecular Formula:C4H6O
    • Molecular Weight:70.091
    • Appearance/Colour:clear colourless to light yellow liquid 
    • Vapor Pressure:1.67mmHg at 25°C 
    • Melting Point:- 2.2 °C(lit.) 
    • Refractive Index:n20/D 1.453(lit.)  
    • Boiling Point:148 °C at 760 mmHg 
    • PKA:13.14±0.10(Predicted) 
    • Flash Point:51.7 °C 
    • PSA:20.23000 
    • Density:0.929 g/cm3 
    • LogP:0.00200 

    2-Butyn-1-ol(Cas 764-01-2) Usage

    InChI:InChI=1/C4H6O/c1-2-3-4-5/h5H,4H2,1H3

    764-01-2 Relevant articles

    BiCl3-Facilitated removal of methoxymethyl-ether/ester derivatives and DFT study of -O-C-O- bond cleavage

    Pacherille, Angela,Tuga, Beza,Hallooman, Dhanashree,Dos Reis, Isaac,Vermette, Mélodie,Issack, Bilkiss B.,Rhyman, Lydia,Ramasami, Ponnadurai,Sunasee, Rajesh

    supporting information, p. 7109 - 7116 (2021/05/03)

    A simple method for the cleavage of meth...

    Synthesis and Photoswitching Properties of Bioinspired Dissymmetric I-Pyrone, an Analogue of Cyclocurcumin

    Pecourneau, Jérémy,Losantos, Raúl,Monari, Antonio,Parant, Stéphane,Pasc, Andreea,Mourer, Maxime

    , p. 8112 - 8126 (2021/06/30)

    Cyclocurcumin (CC), a turmeric curcumino...

    Catalytic asymmetric synthesis of 2,5-dihydrofurans using synergistic bifunctional Ag catalysis

    Shi, Taoda,Teng, Shenghan,Gopi Krishna Reddy, Alavala,Guo, Xin,Zhang, Yueteng,Moore, Kohlson T.,Buckley, Thomas,Mason, Damian J.,Wang, Wei,Chapman, Eli,Hu, Wenhao

    supporting information, p. 8737 - 8744 (2019/10/16)

    We report a bifunctional Ag catalyst pro...

    Nickel(II)-Catalyzed Asymmetric Propargyl [2,3] Wittig Rearrangement of Oxindole Derivatives: A Chiral Amplification Effect

    Xu, Xi,Zhang, Jianlin,Dong, Shunxi,Lin, Lili,Lin, Xiaobin,Liu, Xiaohua,Feng, Xiaoming

    supporting information, p. 8734 - 8738 (2018/07/14)

    A highly enantioselective [2,3] Wittig r...

    764-01-2 Process route

    3-chloro-2-buten-1-ol
    37428-46-9,37428-53-8,40605-42-3

    3-chloro-2-buten-1-ol

    methyl propargyl alcohol
    764-01-2

    methyl propargyl alcohol

    Conditions
    Conditions Yield
    With sodium hydroxide; In cyclohexane; water; at 65 - 72 ℃; for 8h;
    88.1%
    With potassium hydroxide; tetra-(n-butyl)ammonium iodide; In hexane; for 12h; Heating;
    50%
    With ammonia; sodium; ferric nitrate; for 14h;
    47%
    With ammonia; sodium amide; Behandeln des Reaktions-Loesung mit NH4Cl;
    With ammonia; sodium amide;
    propargyl alcohol
    107-19-7

    propargyl alcohol

    methyl iodide
    74-88-4

    methyl iodide

    methyl propargyl alcohol
    764-01-2

    methyl propargyl alcohol

    Conditions
    Conditions Yield
    With lithium; ferric nitrate; In ammonia; at -50 ℃; for 2h;
    95%
    With lithium amide; In ammonia;
    78%
    Multistep reaction;
    methyl iodide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 25 ℃; for 0.166667h; Inert atmosphere;
    propargyl alcohol; at 25 ℃; for 10h; Inert atmosphere;

    764-01-2 Upstream products

    • 50-00-0
      50-00-0

      formaldehyd

    • 16466-97-0
      16466-97-0

      1-propynylmagnesium bromide

    • 37428-46-9
      37428-46-9

      (Z)-3-chloro-2-but-en-1-ol

    • 4089-67-2
      4089-67-2

      2,3-dichloro-1-butanol

    764-01-2 Downstream products

    • 504-61-0
      504-61-0

      (E)-but-2-enol

    • 4088-60-2
      4088-60-2

      cis-2-buten-1-ol

    • 590-93-2
      590-93-2

      2-Butynoic acid

    • 3355-17-7
      3355-17-7

      1-chloro-2-butyne

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