[2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido
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Product Name :
[2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido
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CAS No :
154057-58-6
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Project State :
Commercial
Application
General Description
Good factory exports good [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido 154057-58-6
- Molecular Formula:C37H30BrFNP
- Molecular Weight:618.51700
- Appearance/Colour:White crystalline powder
- Melting Point:218-225℃
- PSA：26.48000
- LogP:5.41640
154057-58-6 Relevant articles
A novel preparation method of a pitavastatin calcium intermediate
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Paragraph 0021-0032, (2019/07/11)
The invention relates to a preparation m...
The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin
Fabris, Jan,Casar, Zdenko,Smilovic, Ivanagazi
experimental part, p. 1700 - 1710 (2012/07/27)
A concise and simple synthetic route to ...
METHOD FOR PREPARATION OF PITAVASTATIN AND ITS PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
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Page/Page column 9-10, (2012/02/03)
The present invention discloses a compou...
PITAVASTATIN CALCIUM AND PROCESS FOR ITS PREPARATION
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Page/Page column 21, (2012/03/26)
The invention provides the process for t...
154057-58-6 Process route
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154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline
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603-35-0
triphenylphosphine
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154057-58-6
<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyltriphenylphosphonium bromide
| Conditions | Yield |
|---|---|
|
In
toluene;
for 5h;
Heating;
|
100% |
|
In
tetrahydrofuran;
at 50 ℃;
for 0.5h;
|
90% |
|
In
toluene;
at 110 ℃;
for 1h;
|
|
|
In
isopropyl alcohol; toluene;
at 25 - 50 ℃;
for 4h;
Industry scale;
|
|
|
In
isopropyl alcohol; toluene;
at 50 ℃;
for 3h;
Industry scale;
|
|
|
In
isopropyl alcohol; toluene;
at 50 ℃;
|
|
|
In
dichloromethane;
Reflux;
|
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-
603-35-0
triphenylphosphine
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121659-86-7
methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate
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154057-58-6
<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyltriphenylphosphonium bromide
| Conditions | Yield |
|---|---|
|
methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate;
In
toluene;
at 25 ℃;
for 5h;
Inert atmosphere;
With
phosphorus tribromide;
In
dichloromethane;
for 3h;
triphenylphosphine;
In
dichloromethane;
at 40 ℃;
for 2h;
|
154057-58-6 Upstream products
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154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline
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603-35-0
triphenylphosphine
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121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline
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121659-86-7
methyl 4-(4'-fluorophenyl)-2-cyclopropylquinoline-3-carboxylate
154057-58-6 Downstream products
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147511-70-4
(R)-1-phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
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147489-06-3
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester