(1S-4R)-4-[[(1,1-diMethylethoxy)carbonyl]aMino]- 2-Cyclopentene-1-carboxylic acid Methyl ester
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Product Name :
(1S-4R)-4-[[(1,1-diMethylethoxy)carbonyl]aMino]- 2-Cyclopentene-1-carboxylic acid Methyl ester
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CAS No :
229613-93-8
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Project State :
Commercial
Application
General Description
Manufacturers supply cost-effective and customizable (1S-4R)-4-[[(1,1-diMethylethoxy)carbonyl]aMino]- 2-Cyclopentene-1-carboxylic acid Methyl ester 229613-93-8
- Molecular Formula:C18H30N2O5
- Molecular Weight:354.44
- PKA:11.61±0.60(Predicted)
- PSA：89.71000
- Density:1.227 g/cm3
- LogP:2.51980
(1S-4R)-4-[[(1,1-diMethylethoxy)carbonyl]aMino]- 2-Cyclopentene-1-carboxylic acid Methyl ester(Cas 229613-93-8) Usage
InChI:InChI=1S/C12H19NO4/c1-12(2,3)17-11(15)13-9-6-5-8(7-9)10(14)16-4/h5-6,8-9H,7H2,1-4H3,(H,13,15)/t8-,9+/m1/s1
229613-93-8 Relevant articles
Substituent and solvent effects in the 1,3-dipolar cycloadditions for synthesis of anti-influenza agent peramivir and its analog
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The invention provides a compound, a pre...
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229613-93-8 Process route
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![(3aR,4R,6S,6aS)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1'-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carboxylic acid tert-butylamine](/upload/2025/9/948f730f-d58e-4596-9ac8-bb28a141f030.png)
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316173-28-1
(3aR,4R,6S,6aS)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1'-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carboxylic acid tert-butylamine
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-
77-78-1
dimethyl sulfate
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![(+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate](/upload/2025/9/73ab9227-b52d-4f6f-ac6a-7ca842bb9584.png)
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229613-93-8
(+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate
| Conditions | Yield |
|---|---|
|
(3aR,4R,6S,6aS)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1'-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carboxylic acid tert-butylamine;
With
potassium carbonate; sodium hydroxide;
In
water; acetone;
Industry scale;
dimethyl sulfate;
In
water; acetone;
at 30 - 45 ℃;
With
ammonia;
In
methanol; water; acetone;
at 0 - 20 ℃;
for 1.25h;
Industry scale;
|
97.13% |
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49805-57-4
2-ethylbutyraldehyde oxime
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![(1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate](/upload/2025/9/cb7b85b2-c958-4097-9d13-8aec1d3869cd.png)
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168683-02-1
(1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate
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-
229613-93-8
(+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate
| Conditions | Yield |
|---|---|
|
With
sodium hypochlorite; triethylamine;
In
water; toluene;
at 60 ℃;
for 28h;
|
59% |
|
With
sodium hypochlorite; triethylamine;
In
dichloromethane;
for 44h;
Reflux;
|
57% |
229613-93-8 Upstream products
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7796-76-1
2-ethyl-1-nitrobutane
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168683-02-1
(1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate
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103-71-9
phenyl isocyanate
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79200-56-9
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
229613-93-8 Downstream products
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1988779-13-0
(1S,2S,3S,4R)-methyl 3-((S)-1-amino-2-ethylbutyl)-4-(tert-butoxycarbonylamino)-2-hydroxycyclopentanecarboxylate
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229614-05-5
(-)-methyl (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(tert-butoxycarbonyl)amino]-2-hydroxycyclopentanecarboxylate
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229614-55-5
peramivir
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1469338-58-6
(1S,2S,3R,4R)-methyl-3-((S)-1-acetamido-2-ethylbutyl)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-2-(((3-(((E)-3-(3,4-bis(allyloxy)phenyl)acryloyl)oxy)propyl)carbamoyl)oxy)cyclopentanecarboxylate