1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol
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Product Name :
1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol
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CAS No :
122431-37-2
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Project State :
Commercial
Application
General Description
Cost-effective and customizable 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol 122431-37-2 for sale
- Molecular Formula:C5H5F3N2O
- Molecular Weight:166.103
- Appearance/Colour:light yellow crystalline powder or needles
- Vapor Pressure:0.061mmHg at 25°C
- Melting Point:177-179 ºC
- Refractive Index:1.471
- Boiling Point:106.4°Cat760mmHg
- PKA:8.08±0.28(Predicted)
- Flash Point:18.1°C
- PSA：38.05000
- Density:1.423g/cm3
- LogP:1.14450
1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol(Cas 122431-37-2) Usage
InChI:InChI=1/C5H5F3N2O/c1-10-4(11)2-3(9-10)5(6,7)8/h2,11H,1H3
122431-37-2 Relevant articles
Regiospecific synthesis of polyfluorinated heterocycles
Martins, Marcos A.P.,Pereira, Claudio M.P.,Zimmermann, Nilo E.K.,Cunico, Wilson,Moura, Sidnei,Beck, Paulo,Zanatta, Nilo,Bonacorso, Helio G.
, p. 261 - 265 (2003)
A series of 10 heterocycles was obtained...
New one-pot synthesis of 4-hydroxyimino-5-polyfluoroalkylpyrazol-3-ones, their structure and biological activity
Burgart, Yanina V.,Agafonova, Natalya A.,Shchegolkov, Evgeny V.,Maslova, Vera V.,Triandafilova, Galina A.,Solodnikov, Sergey Yu.,Krasnykh, Olga P.,Saloutin, Victor I.
, p. 52 - 59 (2019)
[Figure not available: see fulltext.] We...
Pyroxasulfone synthesis method
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Paragraph 0037; 0078; 0085-0086, (2020/07/21)
The invention provides a pyroxasulfone s...
Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety
Si, Wei-Jie,Wang, Xiao-Bin,Chen, Min,Wang, Meng-Qi,Lu, Ai-Min,Yang, Chun-Long
, p. 3000 - 3010 (2019/02/17)
A series of novel pyrazole carboxamide a...
A new method for making pyrazole or pyrimidinone
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Paragraph 0294-0297, (2019/11/28)
The invention relates to the use of an a...
122431-37-2 Process route
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372-31-6
ethyl 4,4,4-trifluoroacetoacetate
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60-34-4
methylhydrazine
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122431-37-2
2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol
| Conditions | Yield |
|---|---|
|
With
acetic acid;
at 0 - 80 ℃;
for 5h;
|
90% |
|
With
hydrogenchloride;
In
ethanol; water;
for 48h;
Reflux;
|
89% |
|
With
hydrogenchloride;
In
ethanol; water;
for 48h;
Reflux;
|
89% |
|
With
hydrogenchloride;
In
ethanol; water;
for 48h;
Reflux;
|
89% |
|
With
hydrogenchloride;
In
ethanol;
for 2h;
Reflux;
|
89% |
|
In
ethanol; water;
at 110 ℃;
Temperature;
Flow reactor;
|
88% |
|
With
sulfuric acid;
In
water;
at 85 ℃;
for 2h;
Reagent/catalyst;
Temperature;
|
87.5% |
|
With
acetic acid;
In
water;
at 10 - 80 ℃;
for 7h;
|
86.5% |
|
ethyl 4,4,4-trifluoroacetoacetate; methylhydrazine;
With
acetic acid;
In
water;
at 10 - 80 ℃;
for 7h;
With
sodium hydroxide; water;
In
toluene;
at 20 ℃;
With
hydrogenchloride; water;
|
86.5% |
|
ethyl 4,4,4-trifluoroacetoacetate; methylhydrazine;
In
ethanol;
at 4 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
ethanol; water;
for 13h;
Reflux;
|
86.5% |
|
In
ethanol;
at 65 ℃;
for 8h;
Reflux;
|
80.3% |
|
With
hydrogenchloride;
In
ethanol; water;
for 48h;
Heating / reflux;
|
72.2% |
|
With
hydrogenchloride;
In
ethanol;
Heating;
|
|
|
With
sulfuric acid;
In
ethanol;
for 17h;
Heating;
|
|
|
In
toluene;
|
|
|
at 30 ℃;
|
-
-
944546-18-3
ethyl-4,4,4-trifluoromethylacetoacetate
-
-
60-34-4
methylhydrazine
-
-
122431-37-2
2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol
| Conditions | Yield |
|---|---|
|
ethyl-4,4,4-trifluoromethylacetoacetate; methylhydrazine;
In
ethanol;
at 20 - 80 ℃;
for 15h;
With
sodium hydroxide;
In
ethanol;
at 20 ℃;
for 1h;
|
97% |
122431-37-2 Upstream products
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372-31-6
ethyl 4,4,4-trifluoroacetoacetate
-
60-34-4
methylhydrazine
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79424-03-6
ethyl 4,4,4-trifluoro-2-butynate
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40657-29-2
1,1,1-trifluoro-4,4-diethoxy-3-buten-2-one
122431-37-2 Downstream products
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179732-64-0
5-hydroxy-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde
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481664-22-6
1-methyl-3-(trifluoromethyl)pyrazol-5-yl 2,4-dichlorobenzenesulfonate
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946409-57-0
5-benzyloxy-4-hydroxymethyl-1-methyl-3-trifluoromethylpyrazole