Good factory supply good 1-Methyl-5-(β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione 13860-38-3 We supply high quality 1-methylpseudouridine (CAS 13860-38-3), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the 1-methylpseudouridine ?

1-methylpseudouridine is , while it's Molecular Formula is C10H14 N2 O6. Used in Biotechnology and Pharmaceutical Industry:
1-Methylpseudouridine is used as a substitute for uridine in modified mRNA for various applications in the biotechnology and pharmaceutical industries. The substitution of uridine with 1-methylpseudouridine in mRNA has been shown to increase transfection efficiency by reducing immunogenicity. This is achieved by the modified mRNA's ability to evade detection by the edosomal Toll-like receptor (TLR3), which leads to lower immune stimulation and consequently, enhanced protein expression.

What is the CAS number for 1-methylpseudouridine ?

The CAS number of 1-methylpseudouridine is 13860-38-3.

More information of 1-methylpseudouridine 13860-38-3 are:

What is 1-methylpseudouridine (13860-38-3) used for?

N1-Methylpseudouridine is a modified nucleoside used for enhancing mRNA translation. Incorporation of N1-Methylpseudouridine into mRNA turns off the immune/eIF2α phosphorylation-dependent inhibition of translation, and increases ribosome pausing and density on the mRNA, thus dramatically facilitating the translation process. N1-Methylpseudouridine outperforms several other modified nucleosides (e.g. 5-Methylcytidine) and corresponding combinations in terms of translation capacity.

InChI:InChI=1/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)

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