mechanism of action

Hexaflumuron is an insect growth regulator (IGR) that works by inhibiting the insect’s growth. It interferes with chitin synthesis, which termites need to form a new exoskeleton.Hexaflumuron is part of a pest monitoring system and is used selectively only in baiting stations where termite activity is present and only when the activity continues. Termites are social insects that share food and feeding sites. Foraging termites recruit nestmates to feeding sites by leaving a pheromone trail to the site, allowing the entire nest to feed on the bait containing hexaflumuron.Pest control operators use hexaflumuron as part of aboveground and underground baiting systems. They place it in a tamper-resistant bait station where foraging termites consume it.

toxicity

AnimalsHexaflumuron has a low toxicity when fed to rats in laboratory studies. See boxes on LD50,Laboratory Testing box and Toxicity Categories.Laboratory tests indicate hexaflumuron is nonirritating to the skin and eyes of rabbits.HumansScientists do not consider hexaflumuron a skin sensitizer.

reference

http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_091b/0901b8038091b652.pdf?filepath=productsafety/pdfs/noreg/233-00932.pdf&fromPage=GetDochttp://npic.orst.edu/factsheets/hexgen.pdfhttp://www.doityourselftermitecontrol.com/chemical-termite-treatments.htmlhttps://www.caymanchem.com/product/18598http://dissemination.echa.europa.eu/Biocides/ActiveSubstances/1314-18/1314-18_Assessment_Report.pdfhttps://npic.orst.edu/factsheets/archive/hextech.pdfhttps://www.epestcontrol.com/images/Products/labels/hexaflumeroninfosheet.pdf

Potential Exposure

Hexaflumuron is a benzoyl urea insecti cide, termiticide and insect growth regulator (IGR) that inhi bits an insect’s growth through chitin synthesis, which termites need to form an exoskeleton. It is used to impregnate termite bait. Worldwide, there are more than 20 suppliers/ manufacturers; most are in the United States Not currently registered for agricultural use in some EU countries.

Metabolic pathway

Although there is limited dormation on the metabolism of hexaflumuron in the open literature, there is a useful summary provided by Dow Agrosciences (Anon). Metabolic pathways are shown in Scheme 1.

Degradation

Hexaflumuron is stable to hydrolysis at pH 5.0 (25°C) over 33 days and hydrolysis at pH 7.0 is slow (6% in 33 days). However, hydrolysis at pH 9.0 was more rapid (DT50 21-23 days). Alkaline hydrolysis followed two separate routes, namely the formation of 2,6-difluorobenzoic acid (2) and 3,5-dichloro-4-( 1,1,2,2-tetrafluoroethoxy)phenylurea (3) and a slower reaction to form 2,6-difluorobenzamide (4) and 3,5-dichloro-4-( 1,1,2,2- tetrafluoroethoxy)anilhe (5). When [14C-aniline] and [14C-benzoyl]hexaflumuron were irradiated in sterile aqueous buffer at pH 5, the DT50 was approximately 6.3 days. The major photolysis product from the benzoyl label was 4 (96% of the applied radioactivity) and from the aniline label was 3,5-dichloro-4- hydroxyaniline (6). The latter comprised 35% of the applied radioactivity and a further 60% was released as 14CO2 from the aniline label indicating extensive ring-opening.

Incompatibilities

Decomposes in temperatures above 275 C. Irritating or toxic fumes or gases in a fire

Waste Disposal

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved land fill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

uses

Hexaflumuron is used to control subterranean termite colonies. It is used in above-ground and inground bait stations as part of termite monitoring and control programs. Target sites include buildings, fences, utility poles, decking, landscape plantings, trees, and other wood structures that can be damaged by termite foraging and feeding. Hexaflumuron products are used only by licensed pest management professionals.Hexaflumuron is registered by the U.S. Environmental Protection Agency (EPA) for use as termite bait. End-use termite bait formulations containing hexaflumuron are registered and sold in more than 25 countries including Australia, Brazil, China, France, Japan, Spain, and the United States. Formulations are packaged into bait stations for in-ground installation around structures and in stations for above-ground installation.

Definition

ChEBI: An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.