Pharmaceutial Intermediates
  • 2-Methylpiperazine

    • Product Name   :   

      2-Methylpiperazine

    • CAS No   :   

      109-07-9

    • Project State   :   

      Commercial

    Application

    General Description

    Cost-effective and customizable 2-Methylpiperazine 109-07-9 for sale

    • Molecular Formula:C5H12N2
    • Molecular Weight:100.164
    • Appearance/Colour:white to yellow crystalline powder and chunks 
    • Vapor Pressure:0.008mmHg at 25°C 
    • Melting Point:61-63 °C(lit.) 
    • Refractive Index:1.459 
    • Boiling Point:153.2 °C at 760 mmHg 
    • PKA:pK1:5.62(+2);pK2:9.60(+1) (25°C) 
    • Flash Point:45.1 °C 
    • PSA:24.06000 
    • Density:0.845 g/cm3 
    • LogP:0.22530 

    2-Methylpiperazine(Cas 109-07-9) Usage

    Purification Methods

    Purify it by zone melting and by distillation. It is hygroscopic. The picrate has m 275-276o. [Beilstein 23 II 16, 23 III/IV 393, 23/3 V 267.]

    InChI:InChI=1/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3

    109-07-9 Relevant articles

    -

    Kitchen,Pollard

    , p. 854 (1947)

    -

    Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

    Borlinghaus, Niels,Gergel, Sebastian,Nestl, Bettina M.

    , p. 3727 - 3732 (2018/04/14)

    Given the widespread importance of piper...

    Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

    Marichev, Kostiantyn O.,Takacs, James M.

    , p. 2205 - 2210 (2016/04/26)

    A new ruthenium complex catalyzes the am...

    Production of phenylpiperazines

    -

    Paragraph 0065, (2017/06/24)

    PROBLEM TO BE SOLVED: To provide a metho...

    METHOD FOR PRODUCING AMINES FROM GLYCERIN

    -

    Page/Page column 10, (2010/10/03)

    The present invention relates to a proce...

    109-07-9 Process route

    glycerol
    56-81-5,25618-55-7,64333-26-2,8013-25-0

    glycerol

    piperazine
    110-85-0

    piperazine

    N-(1-aminomethyl-2-hydroxyethyl)amine
    2811-20-3

    N-(1-aminomethyl-2-hydroxyethyl)amine

    1,2,3-triaminopropane
    21291-99-6

    1,2,3-triaminopropane

    (RS)-2-methylpiperazine
    109-07-9

    (RS)-2-methylpiperazine

    ethylenediamine
    107-15-3,85404-18-8

    ethylenediamine

    1,2-diaminopropan
    78-90-0,10424-38-1

    1,2-diaminopropan

    3,5-dimethylpiperazine
    108-49-6

    3,5-dimethylpiperazine

    Conditions
    Conditions Yield
    With ammonia; hydrogen; Raney nickel; In water; at 200 ℃; under 15001.5 - 150015 Torr; Product distribution / selectivity; Autoclave;
    glycerol
    56-81-5,25618-55-7,64333-26-2,8013-25-0

    glycerol

    2-Amino-1-propanol
    6168-72-5

    2-Amino-1-propanol

    N-(1-aminomethyl-2-hydroxyethyl)amine
    2811-20-3

    N-(1-aminomethyl-2-hydroxyethyl)amine

    1,2,3-triaminopropane
    21291-99-6

    1,2,3-triaminopropane

    (RS)-2-methylpiperazine
    109-07-9

    (RS)-2-methylpiperazine

    1,2-diaminopropan
    78-90-0,10424-38-1

    1,2-diaminopropan

    3,5-dimethylpiperazine
    108-49-6

    3,5-dimethylpiperazine

    2,5-dimethylpiperazine
    106-55-8

    2,5-dimethylpiperazine

    Conditions
    Conditions Yield
    With ammonia; hydrogen; catalyst precursor whose active composition comprised 13% by weight of Cu, calculated as CuO, 28% by weight of Ni, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2; In water; at 180 ℃; for 53h; under 150015 Torr; Product distribution / selectivity;

    109-07-9 Upstream products

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      Glyoxal

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      1,2-diaminopropan

    • 57-55-6
      57-55-6

      propylene glycol

    109-07-9 Downstream products

    • 110331-69-6
      110331-69-6

      2-(3-methyl-piperazino)-1,1-diphenyl-ethanol

    • 3477-42-7
      3477-42-7

      1-(2-hydroxyethyl)-2-methylpiperazine

    • 59215-34-8
      59215-34-8

      2-(3-methyl-piperazin-1-yl)-pyrimidine

    • 120-85-4
      120-85-4

      2-methyl-N,N'-dimethylpiperazine

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